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If It Goes up, Must It Come Down? Chronic Stress and the Hypothalamic-Pituitary Adrenocortical Axis in Humans
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Miller, Gregory E.; Chen, Edith; Zhou, Eric S. – Psychological Bulletin, 2007
The notion that chronic stress fosters disease by activating the hypothalamic-pituitary adrenocortical (HPA) axis is featured prominently in many theories. The research linking chronic stress and HPA function is contradictory, however, with some studies reporting increased activation, and others reporting the opposite. This meta-analysis showed…
Descriptors: Posttraumatic Stress Disorder, Stress Variables, Meta Analysis, Research Problems