Integrating agent-based models (ABMs) has been a popular approach for teaching emergent science concepts. However, students continue to find it difficult to explain the emergent process of natural selection. This study adopted an ontological framework--the Pattern, Agents, Interactions, Relations, and Causality (PAIR-C)--to guide the design of…

In recent years, modern technologies have enabled the collection of exponentially larger quantities of data in the biomedical domain and elsewhere. In particular, the advent of single-cell genomics has allowed for the collection of datasets containing hundreds of thousands of cells measured in tens of thousands of dimensions. This rapid expansion…

Soft rot diseases cause crop losses all over the world. These losses can have large economic impacts and threaten international food security. Soft rot bacterial pathogens produce pectolytic enzymes that attack the pectin around plant cells resulting in smelly, wet, and mushy tissue maceration. Once symptoms are visible, the crop cannot be used or…

Humans have long sought to understand the forces that shape the diversity of living creatures on our planet. This work is primarily concerned with examining one such force--the historical action of natural selection--from practical, philosophical, and pedagogical perspectives. The first half is concerned with a suite of genetic mechanisms in…

Biology and biotechnology are increasingly ubiquitous and genome research will define the 21st century as the century of biology (Venter & Cohen, 2004). Comprehension of biology is needed to engage with major public policy issues and to make informed decisions (Barton & Uphadyay, 2010; Ladson-Billings, 2003; NRC, 2012; Walker, 2021).…

Despite the number of university students who take courses in multiple science disciplines, little is known about how they perceive common concepts from different disciplinary perspectives and to what extent they recognize connections among their courses. This dissertation explores students' perceptions of their chemistry and biology courses…

Multiple models of the gene are used to explore genetic phenomena in scientific practices and in the classroom. In genetics curricula, the classical and molecular models are presented in disconnected domains. Research demonstrates that, without explicit connections, students have difficulty developing an understanding of the gene that spans…

Chapter 1: The role of cell division in protein expression is important to understand in order to guide the development of better nonviral gene delivery materials that can transport DNA to the nucleus with high efficiency for a variety of cell types, particularly when nondividing cells are targets of gene therapy. We evaluated the relationship…

Traditional undergraduate biology courses are content intensive, requiring students to understand and remember large amounts of information in short periods of time. Yet most students maintain little of the material encountered during their education. Poor knowledge retention is a main cause of academic failure and high undergraduate attrition…

A recent focus on contemporary evolution and the connections between communities has sought to more closely integrate ecology with evolutionary biology. Studies of coevolutionary dynamics, life history evolution, and rapid local adaptation demonstrate that ecological circumstances can dictate evolutionary trajectories. Thus, variation in species…

The main goal of school science is to enable learners to become scientifically literate through their participation in scientific discourses (McNeill & Krajcik, 2009). One of the key elements of scientific discourses is the ability to construct scientific explanations that consist of valid claims supported by appropriate evidence (e.g., McNeill &…