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Direct linkJia, Margaret; Travaglia, Alessio; Pollonini, Gabriella; Fedele, Giuseppe; Alberini, Cristina M. – Learning & Memory, 2018
The medial prefrontal cortex (mPFC) plays a critical role in complex brain functions including decision-making, integration of emotional, and cognitive aspects in memory processing and memory consolidation. Because relatively little is known about the molecular mechanisms underlying its development, we quantified rat mPFC basal expression levels…
Descriptors: Animals, Brain Hemisphere Functions, Biochemistry, Cognitive Processes
Vecsey, Christopher G.; Park, Alan J.; Khatib, Nora; Abel, Ted – Learning & Memory, 2015
Sleep deprivation (SD) following hippocampus-dependent learning in young mice impairs memory when tested the following day. Here, we examined the effects of SD on remote memory in both young and aged mice. In young mice, we found that memory is still impaired 1 mo after training. SD also impaired memory in aged mice 1 d after training, but, by a…
Descriptors: Sleep, Memory, Neurological Impairments, Animals
Verbitsky, Miguel; Yonan, Amanda L.; Malleret, Gael; Kandel, Eric R.; Gilliam, T. Conrad; Pavlidis, Paul – Learning & Memory, 2004
We have carried out a global survey of age-related changes in mRNA levels in the 57BL/6NIA mouse hippocampus and found a difference in the hippocampal gene expression profile between 2-month-old young mice and 15-month-old middle-aged mice correlated with an age-related cognitive deficit in hippocampal-based explicit memory formation. Middle-aged…
Descriptors: Profiles, Animals, Memory, Brain Hemisphere Functions
